Supramolecular organization of ATP synthase and respiratory chain in mitochondrial membranes
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چکیده
منابع مشابه
Cardiolipin affects the supramolecular organization of ATP synthase in mitochondria.
F(1)F(0) ATP synthase forms dimers that tend to assemble into large supramolecular structures. We show that the presence of cardiolipin is critical for the degree of oligomerization and the degree of order in these ATP synthase assemblies. This conclusion was drawn from the statistical analysis of cryoelectron tomograms of cristae vesicles isolated from Drosophila flight-muscle mitochondria, wh...
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The ATP synthase is a nanometric rotary machine that uses a transmembrane electrochemical gradient to form ATP. The structures of most components of the ATP synthase are known, and their organization has been elucidated. However, the supramolecular assembly of ATP synthases in biological membranes remains unknown. Here we show with submolecular resolution the organization of ATP synthases in th...
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The existence of specific respiratory supercomplexes in mitochondria of most organisms has gained much momentum. However, its functional significance is still poorly understood. The availability of many deletion mutants in complex I (NADH:ubiquinone oxidoreductase) of Neurospora crassa, distinctly affected in the assembly process, offers unique opportunities to analyze the biogenesis of respira...
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72 h The primary function of the mitochondrial respiratory chain is to generate energy in the form of ATP via the four complexes of the electron transport chain and the ATP synthetase. Damage to one or more of the respiratory chain complexes may therefore result in depletion of cellular energy reserves and cell death. There is increasing evidence that defects in mitochondrial energy metabolism ...
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The structures of the ATP synthases in bacteria and mitochondria are very similar (for reviews see Senior, 1979; Fillingame, 1981 ; Racker, 1981 ; Walker et al., 1982). They are membrane-bound enzymes composed of two distinct domains: a domain called F, which is buried in the membrane and attached to it a domain known as F, which lies outside the membrane (see Fig. 1). F, is composed of five di...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Bioenergetics
سال: 2009
ISSN: 0005-2728
DOI: 10.1016/j.bbabio.2008.12.016